Cetylpyridinium chloride (CPC)
What is it?
Cetylpyridinium chloride (CPC) is an effective oral antiseptic that helps protect the mouth by eliminating bacteria. In addition, it enhances the effect of chlorhexidine (CHX) and has been shown to be useful in preventing and reducing the action of viruses such as the flu, COVID-19, and cold sores.
For this reason, it is widely used in toothpastes and mouthwashes for the prevention of oral diseases.
Recommendations
Mouthwashes containing CPC may reduce the infectivity of certain viruses
The use of mouthwashes containing CPC may offer an additional safe, simple and cost-effective way to reduce the infectivity and transmission potential of certain viruses.
Incorporating CPC into your oral hygiene routine could be a preventative antiviral option
The oral cavity is a primary entry point for pathogens into the body. Regular use of mouthwashes containing CPC not only helps to reduce bacterial plaque build-up, but may also lower the risk of transmitting certain viruses.
Using CPC in high-risk environments may support protecting people
In high-exposure settings like clinics and hospitals, CPC-based mouthwashes serve as an additional protective measure, as they may significantly reduce the intraoral viral load and may help prevent infections.
Indications
What it is used for
Reduces the infectivity of respiratory viruses. Helps control and prevent herpes simplex type 1 (HSV-1). Serves as an antiseptic for daily oral hygiene. Acts as a preventive antiviral measure in healthcare settings. Supports the treatment of periodontal diseases. Improves oral health in immunosuppressed individuals. Reduces bad breath (halitosis) when combined with tongue cleaning. Enhances postoperative oral healthcare. Prevents infections associated with orthodontic treatment. Controls infections associated with dental prostheses.
Studies supporting its efficacy
- In vitro study by the IrsiCaixa AIDS Research Institute and the Dentaid Research Center
Shows that mouthwashes containing cetylpyridinium chloride (CPC) can reduce the infectivity of the herpes simplex virus type 1 (HSV-1) in cell cultures. Published in the scientific journal "Viruses", the study suggests that CPC can play a significant role as an antiviral, in addition to being effective as an oral antiseptic. It reaffirms the ability of CPC to reduce the infectivity of certain viruses by up to 100 times, given that the compound had already shown its effectiveness against viruses such as influenza or SARS-CoV-2 in previous in vitro and in vivo studies.
- Study led by Dr Fabian Cieplik, an associate professor at the Regensburg University Hospital
A study led by Dr Fabian Cieplik, published in the Journal of Dental Research, has shown that mouthwashes containing chlorhexidine (CHX) and cetylpyridinium chloride (CPC) can significantly reduce viral infectivity in the oral cavity of people with COVID-19.
The study confirms that rinsing for 1 minute with these two active substances can reduce the viral load up to 30 minutes later.
This finding supports earlier research highlighting the effectiveness of antiseptic mouthwashes in reducing the transmission of respiratory viruses, particularly in healthcare settings for both professionals and patients.
Most common profiles
Immunosuppressed individuals
People with weakened immune systems need extra care to prevent infections. Using products containing CPC can help reduce bacteria and viruses in the mouth, offering additional protection. Using them daily could prevent gum and plaque problems, improving oral health and overall well-being.
People who have had a surgical extraction
People having undergone a surgical extraction require specific care to prevent infections and to ensure optimal recovery. Using CPC products may reduce bacteria and viruses in the mouth, providing additional protection in the treated area.
People with gingivitis
People with gingivitis need special care to control inflammation and reduce bacteria. Regular use of CPC products could help maintain healthy gums, prevent disease progression and protect against future complications.
People with orthodontic appliances
Orthodontic patients need to maintain good oral hygiene to prevent infections and plaque build-up around braces. Using CPC products could reduce bacteria in hard-to-reach areas providing extra protection during orthodontic treatment.
People with halitosis
People with halitosis (bad breath) require special care to improve breath freshness. Using CPC products could target the bacteria responsible for bad breath, helping to maintain good oral hygiene and promote a healthier mouth.
People with dentures
Denture wearers must properly clean their appliances to prevent infections and plaque build-up. Using CPC products could reduce bacteria in hard-to-reach areas, enhancing oral hygiene and ensuring a comfortable denture fit.
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