- A study by the International University of Catalonia (UIC Barcelona) and the Dentaid Research Center concludes that controlling oral biofilm (dental plaque) continues to be the best option to prevent peri-implant diseases, although some antibacterial coatings have shown to reduce levels of colonisation and increase bacterial mortality.
- Some implants designed with rougher surfaces to facilitate their integration into bone tissue promote the formation of bacterial biofilm which, over time, can cause diseases like peri-implant mucositis and peri-implantitis.
Barcelona, 28 November 2023.
- Peri-implant diseases are oral infections that involve inflammation of the tissue surrounding dental implants and are very common among the population. According to the Spanish Society of Periodontology and Osseointegration (SEPA), 25% of patients with implants in place for over five years suffer from these diseases.
Poor oral hygiene is the main risk factor for infection. However, scientific and clinical research has propelled a substantial improvement of the design and surface topography of implants in recent decades, and has increased the understanding of bone and soft tissue biology, to help prevent infections. Today, we see that it is important to create implants that adapt to each individual’s oral cavity. However, some modifications aimed at improving an implant’s adaptation to the bone, such as increasing the roughness of the implant material, may favour the adhesion of bacterial biofilm (dental plaque),thereby increasing the likelihood of the development of diseases such as peri-implant mucositis and peri-implantitis.
For this reason, UIC Barcelona’s Bioengineering Institute of Technology and School of Dentistry, in collaboration with the Dentaid Research Center, an oral health research facility, have conducted a study to analyse the effectiveness of a coating containing the Triethoxysilylpropyl Succinic Anhydride Silane molecule (TESPSA) on implants of different roughnesses and to compare it with treatment using citric acid through a process known as passivation. The goal is to reduce the adhesion of microorganisms, thereby promoting an antibacterial effect. The biofilm model developed for this study did not show clear differences between anti-adhesive and bactericidal effects when comparing the surfaces treated with TESPSA or citric acid passivation. However, a tendency to reduce oral biofilm adhesion and to increase antibacterial effects was observed for TESPSA-treated implant coatings. The study concludes that, although lower bacterial colonisation and higher bacterial mortality were observed, further research on implant coatings is necessary to develop effective strategies to prevent peri-implant diseases. Currently, the best option to prevent these diseases remains the control of oral biofilm through strict oral hygiene.
Peri-implant diseases are caused by infections associated with a heterogeneous and complex microbial community. In fact, the accumulation of biofilm around dental implants is one of the risk factors most associated with peri-implant diseases. According to Gerard Álvarez, author of the study and researcher at the Dentaid Research Center: “Dental implants are exposed prostheses. For this reason, patients, dentists and researchers must all strive to reduce the onset of infection.”
Decades of Research
In recent years, several studies have focused on the development of modified surfaces to improve soft tissue healing and reduce biofilm (plaque) overgrowth. Additionally, some research has sought to discover antibacterial solutions to further reduce its viability. This particular research group focused on the TESPSA molecule, which has the ability to enhance osteoinductive and antibacterial surface properties, and on citric acid surface passivation, which reduces the corrosion process and forms a protective layer.
The study analysed the influence of substrate roughness on biofilm adhesion and quantified early bacterial adhesion and cell viability on surfaces coated with TESPSA and passivated with citric acid. As pointed out by Javier Gil, author of the study, researcher at UIC Barcelona and head of the National Peri-implantitis Network granted by the Ministry of Science and Innovation, “Progress in developing antibacterial dental implants requires interdisciplinary studies involving clinicians, microbiologists and biomaterials specialists.” Thus, he concludes: “We still have a long way to go, but we are moving in the right direction.”
About Dentaid
Dentaid is a company with a clear purpose: to promote and improve people's oral health through research, dissemination of knowledge and the development of innovative products. The Dentaid Research Center is where we generate knowledge, share it with professionals and apply it to science-backed oral healthcare solutions. With brands including Vitis®, Interprox®, Perio·Aid® and PHB® we reach over 35 million people in 60 countries. www.dentaid.com
About UIC Barcelona
The International University of Catalonia (UIC Barcelona) was founded in 1997 with the aim of offering quality university education and promoting research as a service to society. With strong ties to the business world and a distinctly international focus, it offers 16 degrees, 8 double degrees, around 30 international dual-degree programs, and an extensive selection of postgraduate programmes across its two campuses, located in Barcelona and Sant Cugat del Vallès. As part of its commitment to society, UIC Barcelona also has three university clinics located on the Sant Cugat Campus: the University Clinic of Dentistry, University Support Clinic of Psychology and Psychiatry and Cuides UIC Barcelona, focused on the care of patients with advanced diseases and on palliative care.
For more information:
Dentaid
dentaid@llorenteycuenca.com
T.: +34 93 217 22 17
UIC Barcelona
Marta González Martínez
mgonzalezmar@uic.es
T. +34 935 042 000. Ext: 5153 / 657 736 887
- A study by the International University of Catalonia (UIC Barcelona) and the Dentaid Research Center concludes that controlling oral biofilm (dental plaque) continues to be the best option to prevent peri-implant diseases, although some antibacterial coatings have shown to reduce levels of colonisation and increase bacterial mortality.
- Some implants designed with rougher surfaces to facilitate their integration into bone tissue promote the formation of bacterial biofilm which, over time, can cause diseases like peri-implant mucositis and peri-implantitis.
Barcelona, 28 November 2023.
- Peri-implant diseases are oral infections that involve inflammation of the tissue surrounding dental implants and are very common among the population. According to the Spanish Society of Periodontology and Osseointegration (SEPA), 25% of patients with implants in place for over five years suffer from these diseases.
Poor oral hygiene is the main risk factor for infection. However, scientific and clinical research has propelled a substantial improvement of the design and surface topography of implants in recent decades, and has increased the understanding of bone and soft tissue biology, to help prevent infections. Today, we see that it is important to create implants that adapt to each individual’s oral cavity. However, some modifications aimed at improving an implant’s adaptation to the bone, such as increasing the roughness of the implant material, may favour the adhesion of bacterial biofilm (dental plaque),thereby increasing the likelihood of the development of diseases such as peri-implant mucositis and peri-implantitis.
For this reason, UIC Barcelona’s Bioengineering Institute of Technology and School of Dentistry, in collaboration with the Dentaid Research Center, an oral health research facility, have conducted a study to analyse the effectiveness of a coating containing the Triethoxysilylpropyl Succinic Anhydride Silane molecule (TESPSA) on implants of different roughnesses and to compare it with treatment using citric acid through a process known as passivation. The goal is to reduce the adhesion of microorganisms, thereby promoting an antibacterial effect. The biofilm model developed for this study did not show clear differences between anti-adhesive and bactericidal effects when comparing the surfaces treated with TESPSA or citric acid passivation. However, a tendency to reduce oral biofilm adhesion and to increase antibacterial effects was observed for TESPSA-treated implant coatings. The study concludes that, although lower bacterial colonisation and higher bacterial mortality were observed, further research on implant coatings is necessary to develop effective strategies to prevent peri-implant diseases. Currently, the best option to prevent these diseases remains the control of oral biofilm through strict oral hygiene.
Peri-implant diseases are caused by infections associated with a heterogeneous and complex microbial community. In fact, the accumulation of biofilm around dental implants is one of the risk factors most associated with peri-implant diseases. According to Gerard Álvarez, author of the study and researcher at the Dentaid Research Center: “Dental implants are exposed prostheses. For this reason, patients, dentists and researchers must all strive to reduce the onset of infection.”
Decades of Research
In recent years, several studies have focused on the development of modified surfaces to improve soft tissue healing and reduce biofilm (plaque) overgrowth. Additionally, some research has sought to discover antibacterial solutions to further reduce its viability. This particular research group focused on the TESPSA molecule, which has the ability to enhance osteoinductive and antibacterial surface properties, and on citric acid surface passivation, which reduces the corrosion process and forms a protective layer.
The study analysed the influence of substrate roughness on biofilm adhesion and quantified early bacterial adhesion and cell viability on surfaces coated with TESPSA and passivated with citric acid. As pointed out by Javier Gil, author of the study, researcher at UIC Barcelona and head of the National Peri-implantitis Network granted by the Ministry of Science and Innovation, “Progress in developing antibacterial dental implants requires interdisciplinary studies involving clinicians, microbiologists and biomaterials specialists.” Thus, he concludes: “We still have a long way to go, but we are moving in the right direction.”
About Dentaid
Dentaid is a company with a clear purpose: to promote and improve people's oral health through research, dissemination of knowledge and the development of innovative products. The Dentaid Research Center is where we generate knowledge, share it with professionals and apply it to science-backed oral healthcare solutions. With brands including Vitis®, Interprox®, Perio·Aid® and PHB® we reach over 35 million people in 60 countries. www.dentaid.com
About UIC Barcelona
The International University of Catalonia (UIC Barcelona) was founded in 1997 with the aim of offering quality university education and promoting research as a service to society. With strong ties to the business world and a distinctly international focus, it offers 16 degrees, 8 double degrees, around 30 international dual-degree programs, and an extensive selection of postgraduate programmes across its two campuses, located in Barcelona and Sant Cugat del Vallès. As part of its commitment to society, UIC Barcelona also has three university clinics located on the Sant Cugat Campus: the University Clinic of Dentistry, University Support Clinic of Psychology and Psychiatry and Cuides UIC Barcelona, focused on the care of patients with advanced diseases and on palliative care.
For more information:
Dentaid
dentaid@llorenteycuenca.com
T.: +34 93 217 22 17
UIC Barcelona
Marta González Martínez
mgonzalezmar@uic.es
T. +34 935 042 000. Ext: 5153 / 657 736 887
Cookie Policy
We use our own and third-party cookies to analyse website usage and display ads tailored to your preferences based on a profile created from your browsing habits (e.g., pages visited).
You can accept or reject all cookies, or customise your preferences.